[HTML][HTML] Possible novel therapeutic targets in lymphangioleiomyomatosis treatment
X Song, H Cai, C Yang, X Xue, J Wang, Y Mo… - Frontiers in …, 2020 - frontiersin.org
Lymphangioleiomyomatosis (LAM) is a rare systemic neoplastic disease that exclusively
happens in women. Studies focusing on LAM and tuberous sclerosis complex (TSC) have
made great progress in understanding the pathogenesis and searching for treatment. The
inactive mutation of TSC1 or TSC2 is found in patients with LAM to activate the crucial
mammalian target of rapamycin (mTOR) signaling pathway and result in enhanced cell
proliferation and migration. However, it does not explain every step of tumorigenesis in LAM …
happens in women. Studies focusing on LAM and tuberous sclerosis complex (TSC) have
made great progress in understanding the pathogenesis and searching for treatment. The
inactive mutation of TSC1 or TSC2 is found in patients with LAM to activate the crucial
mammalian target of rapamycin (mTOR) signaling pathway and result in enhanced cell
proliferation and migration. However, it does not explain every step of tumorigenesis in LAM …
Possible Novel Therapeutic Targets in Lymphangioleiomyomatosis Treatment: A System Review
X Song, L Ye, M Jin - C38. RARE LUNG DISEASES, 2020 - atsjournals.org
Lymphangioleiomyomatosis (LAM) is a rare systemic neoplastic disease that exclusively
happens in women. Clinical manifestations of this low-grade malignant tumor include
dyspnea, wheeze, cough, recurrent spontaneous pneumothorax, chylothorax, hemoptysis,
and a decline in lung function level, as well as renal angiomyolipomas and
lymphangioleiomyomas. The pathological feature of LAM consists of abnormal smooth
muscle cell proliferation in LAM lesions, cystic destruction of the lung tissue, and …
happens in women. Clinical manifestations of this low-grade malignant tumor include
dyspnea, wheeze, cough, recurrent spontaneous pneumothorax, chylothorax, hemoptysis,
and a decline in lung function level, as well as renal angiomyolipomas and
lymphangioleiomyomas. The pathological feature of LAM consists of abnormal smooth
muscle cell proliferation in LAM lesions, cystic destruction of the lung tissue, and …