B7-H3 over expression in prostate cancer promotes tumor cell progression

H Yuan, X Wei, G Zhang, C Li, X Zhang, J Hou - The Journal of urology, 2011 - Elsevier
PURPOSE: We compared B7-H3 expression in benign prostatic hyperplasia and prostate
cancer tissue specimens, and determined the effects of low B7-H3 expression on the PC-3
human prostate cancer cell line using RNA interference. MATERIALS AND METHODS: B7-
H3 expression in prostate specimens was determined by enzyme-linked immunosorbent
assay. A PC-3 cell line with low B7-H3 expression was established by RNA interference to
investigate the effect of B7-H3 on cell proliferation, adhesion, migration and invasion in vitro …