[HTML][HTML] Association of β-arrestin with G protein-coupled receptors during clathrin-mediated endocytosis dictates the profile of receptor resensitization
RH Oakley, SA Laporte, JA Holt, LS Barak… - Journal of Biological …, 1999 - ASBMB
Resensitization of G protein-coupled receptors (GPCRs) following agonist-mediated
desensitization is a necessary step for maintaining physiological responsiveness. However,
the molecular mechanisms governing the nature of GPCR resensitization are poorly
understood. Here, we examine the role of β-arrestin in the resensitization of the β 2
adrenergic receptor (β 2 AR), known to recycle and resensitize rapidly, and the vasopressin
V2 receptor (V2R), known to recycle and resensitize slowly. Upon agonist activation, both …
desensitization is a necessary step for maintaining physiological responsiveness. However,
the molecular mechanisms governing the nature of GPCR resensitization are poorly
understood. Here, we examine the role of β-arrestin in the resensitization of the β 2
adrenergic receptor (β 2 AR), known to recycle and resensitize rapidly, and the vasopressin
V2 receptor (V2R), known to recycle and resensitize slowly. Upon agonist activation, both …
