[HTML][HTML] Gastrointestinal pain: unraveling a novel endogenous pathway through uroguanylin/guanylate cyclase-C/cGMP activation
I Silos-Santiago, G Hannig, H Eutamene, EE Ustinova… - PAIN®, 2013 - Elsevier
The natural hormone uroguanylin regulates intestinal fluid homeostasis and bowel function
through activation of guanylate cyclase-C (GC-C), resulting in increased intracellular cyclic
guanosine-3′, 5′-monophosphate (cGMP). We report the effects of uroguanylin-mediated
activation of the GC-C/cGMP pathway in vitro on extracellular cGMP transport and in vivo in
rat models of inflammation-and stress-induced visceral hypersensitivity. In vitro exposure of
intestinal Caco-2 cells to uroguanylin stimulated bidirectional, active extracellular transport …
through activation of guanylate cyclase-C (GC-C), resulting in increased intracellular cyclic
guanosine-3′, 5′-monophosphate (cGMP). We report the effects of uroguanylin-mediated
activation of the GC-C/cGMP pathway in vitro on extracellular cGMP transport and in vivo in
rat models of inflammation-and stress-induced visceral hypersensitivity. In vitro exposure of
intestinal Caco-2 cells to uroguanylin stimulated bidirectional, active extracellular transport …
