Short-term ibrutinib therapy suppresses skin test responses and eliminates IgE-mediated basophil activation in adults with peanut or tree nut allergy
MC Dispenza, JA Pongracic, AM Singh… - Journal of Allergy and …, 2018 - jacionline.org
To the Editor: There is an obvious unmet need for treatments capable of preventing
anaphylaxis, especially in the case of food allergy, where avoidance of triggers is not always
possible. Bruton's tyrosine kinase (BTK) is a key component of B-cell receptor signaling, and
is also essential for FcεRI signaling and triggering of mast cells and basophils. 1-3 Ibrutinib
(brand name Imbruvica; Janssen Pharmaceuticals [Horsham, Pa] and Pharmacyclics, Inc
[Sunnyvale, Calif]), an irreversible BTK inhibitor that is Food and Drug Administration …
anaphylaxis, especially in the case of food allergy, where avoidance of triggers is not always
possible. Bruton's tyrosine kinase (BTK) is a key component of B-cell receptor signaling, and
is also essential for FcεRI signaling and triggering of mast cells and basophils. 1-3 Ibrutinib
(brand name Imbruvica; Janssen Pharmaceuticals [Horsham, Pa] and Pharmacyclics, Inc
[Sunnyvale, Calif]), an irreversible BTK inhibitor that is Food and Drug Administration …
