A mitochondrial STAT3-methionine metabolism axis promotes ILC2-driven allergic lung inflammation
L Fu, J Zhao, J Huang, N Li, X Dong, Y He… - Journal of Allergy and …, 2022 - Elsevier
Background Group 2 innate lymphoid cells (ILC2s), the innate counterpart of TH 2 cells, play
a critical role in type 2 immune responses. However, the molecular regulatory mechanisms
of ILC2s are still unclear. Objective The aim of this study was to explore the importance of
signal transducer and activator of transcription 3 (STAT3) to ILC2 function in allergic lung
inflammation. Methods Acute and chronic asthma models were established by intranasal
administration of the protease allergen papain in Vav icre Stat3 fl/fl, Il5 tdtomato-cre Stat3 …
a critical role in type 2 immune responses. However, the molecular regulatory mechanisms
of ILC2s are still unclear. Objective The aim of this study was to explore the importance of
signal transducer and activator of transcription 3 (STAT3) to ILC2 function in allergic lung
inflammation. Methods Acute and chronic asthma models were established by intranasal
administration of the protease allergen papain in Vav icre Stat3 fl/fl, Il5 tdtomato-cre Stat3 …