[HTML][HTML] The import of the transcription factor STAT3 into mitochondria depends on GRIM-19, a component of the electron transport chain
P Tammineni, C Anugula, F Mohammed… - Journal of Biological …, 2013 - ASBMB
The signal transducer and activator of transcription 3 (STAT3), a nuclear transcription factor,
is also present in mitochondria and regulates cellular respiration in a transcriptional-
independent manner. The mechanism of STAT3 import into mitochondria remains obscure.
In this report we show that mitochondrial-localized STAT3 resides in the inner mitochondrial
membrane. In vitro import studies show that the gene associated with retinoid interferon
induced cell mortality 19 (GRIM-19), a complex I subunit that acts as a chaperone to recruit …
is also present in mitochondria and regulates cellular respiration in a transcriptional-
independent manner. The mechanism of STAT3 import into mitochondria remains obscure.
In this report we show that mitochondrial-localized STAT3 resides in the inner mitochondrial
membrane. In vitro import studies show that the gene associated with retinoid interferon
induced cell mortality 19 (GRIM-19), a complex I subunit that acts as a chaperone to recruit …