[HTML][HTML] Neurological dysfunction occurs in mice with targeted deletion of the selenoprotein P gene
KE Hill, WJ McMahan, AK Motley, RF Burk, J Zhou - The Journal of nutrition, 2004 - Elsevier
Brain function and selenium concentration are well maintained in rodents under conditions
of selenium deficiency. Recently, however, targeted deletion of the selenoprotein P gene
(Sepp) has been associated with a decrease in brain selenium concentration and with
neurological dysfunction. Studies were conducted with Sepp−/− and Sepp+/+ mice to
characterize the neurological dysfunction and to correlate it with dietary selenium level.
When weanling Sepp−/− mice were fed the basal diet (< 0.01 mg/kg selenium) …
of selenium deficiency. Recently, however, targeted deletion of the selenoprotein P gene
(Sepp) has been associated with a decrease in brain selenium concentration and with
neurological dysfunction. Studies were conducted with Sepp−/− and Sepp+/+ mice to
characterize the neurological dysfunction and to correlate it with dietary selenium level.
When weanling Sepp−/− mice were fed the basal diet (< 0.01 mg/kg selenium) …