Genetic basis of pancreas cancer development and progression: insights from whole-exome and whole-genome sequencing
CA Iacobuzio-Donahue, VE Velculescu… - Clinical cancer …, 2012 - AACR
Clinical cancer research, 2012•AACR
Pancreatic cancer is caused by inherited and acquired mutations in specific cancer-
associated genes. The discovery of the most common genetic alterations in pancreatic
cancer has provided insight into the fundamental pathways that drive the progression from a
normal cell to noninvasive precursor lesions and finally to widely metastatic disease. In
addition, recent genetic discoveries have created new opportunities to develop gene-based
approaches for early detection, personalized treatment, and molecular classification of …
associated genes. The discovery of the most common genetic alterations in pancreatic
cancer has provided insight into the fundamental pathways that drive the progression from a
normal cell to noninvasive precursor lesions and finally to widely metastatic disease. In
addition, recent genetic discoveries have created new opportunities to develop gene-based
approaches for early detection, personalized treatment, and molecular classification of …
Abstract
Pancreatic cancer is caused by inherited and acquired mutations in specific cancer-associated genes. The discovery of the most common genetic alterations in pancreatic cancer has provided insight into the fundamental pathways that drive the progression from a normal cell to noninvasive precursor lesions and finally to widely metastatic disease. In addition, recent genetic discoveries have created new opportunities to develop gene-based approaches for early detection, personalized treatment, and molecular classification of pancreatic neoplasms. Clin Cancer Res; 18(16); 4257–65. ©2012 AACR.
AACR
