[HTML][HTML] Interleukins 19, 20, and 24 signal through two distinct receptor complexes: differences in receptor-ligand interactions mediate unique biological functions
J Parrish-Novak, W Xu, T Brender, L Yao… - Journal of Biological …, 2002 - ASBMB
Cytokines that signal through Class II receptors form a distinct family that includes the
interferons and interleukin 10 (IL-10). Recent identification of several IL-10 homologs has
defined a cytokine subfamily that includes AK155, IL-19, IL-20, IL-22, and IL-24. Within this
subfamily, IL-19, IL-20, and IL-24 exhibit substantial sharing of receptor complexes; all three
are capable of signaling through IL-20RA/IL-20RB, and IL-20 and IL-24 both can also use IL-
22R/IL-20RB. However, the biological effects of these three cytokines appear quite distinct …
interferons and interleukin 10 (IL-10). Recent identification of several IL-10 homologs has
defined a cytokine subfamily that includes AK155, IL-19, IL-20, IL-22, and IL-24. Within this
subfamily, IL-19, IL-20, and IL-24 exhibit substantial sharing of receptor complexes; all three
are capable of signaling through IL-20RA/IL-20RB, and IL-20 and IL-24 both can also use IL-
22R/IL-20RB. However, the biological effects of these three cytokines appear quite distinct …
