Interferon induction by viruses XIII. Detection and assay of interferon induction-suppressing particles
PI Marcus, MJ Sekellick - Virology, 1985 - Elsevier
PI Marcus, MJ Sekellick
Virology, 1985•ElsevierAn assay is described for detecting and measuring the capacity of a single virus particle to
suppress completely the yield of interferon from a cell otherwise competent to produce
interferon. The assay defines virus populations in terms of a newly quantifiable attribute—
interferon induction-suppressing particles (ISP). The antagonistic actions of interferon-
inducing particles and interferon induction-suppressing particles are thought to determine
the interferon-inducing capacity intrinsic to a virus population.
suppress completely the yield of interferon from a cell otherwise competent to produce
interferon. The assay defines virus populations in terms of a newly quantifiable attribute—
interferon induction-suppressing particles (ISP). The antagonistic actions of interferon-
inducing particles and interferon induction-suppressing particles are thought to determine
the interferon-inducing capacity intrinsic to a virus population.
Abstract
An assay is described for detecting and measuring the capacity of a single virus particle to suppress completely the yield of interferon from a cell otherwise competent to produce interferon. The assay defines virus populations in terms of a newly quantifiable attribute—interferon induction-suppressing particles (ISP). The antagonistic actions of interferon-inducing particles and interferon induction-suppressing particles are thought to determine the interferon-inducing capacity intrinsic to a virus population.
Elsevier