[HTML][HTML] Endoplasmic reticulum stress and Ca2+ depletion differentially modulate the sterol regulatory protein PCSK9 to control lipid metabolism
P Lebeau, A Al-Hashimi, S Sood, Š Lhoták, P Yu… - Journal of Biological …, 2017 - ASBMB
Accumulating evidence implicates endoplasmic reticulum (ER) stress as a mediator of
impaired lipid metabolism, thereby contributing to fatty liver disease and atherosclerosis.
Previous studies demonstrated that ER stress can activate the sterol regulatory element-
binding protein-2 (SREBP2), an ER-localized transcription factor that directly up-regulates
sterol regulatory genes, including PCSK9. Given that PCSK9 contributes to atherosclerosis
by targeting low density lipoprotein (LDL) receptor (LDLR) degradation, this study …
impaired lipid metabolism, thereby contributing to fatty liver disease and atherosclerosis.
Previous studies demonstrated that ER stress can activate the sterol regulatory element-
binding protein-2 (SREBP2), an ER-localized transcription factor that directly up-regulates
sterol regulatory genes, including PCSK9. Given that PCSK9 contributes to atherosclerosis
by targeting low density lipoprotein (LDL) receptor (LDLR) degradation, this study …