[HTML][HTML] Zinc finger E-box–binding homeobox 1 (ZEB1) is required for neural differentiation of human embryonic stem cells
Human pluripotent stem cells hold great promise for improving regenerative medicine.
However, a risk for tumor formation and difficulties in generating large amounts of subtype
derivatives remain the major obstacles for clinical applications of stem cells. Here, we
discovered that zinc finger E-box–binding homeobox 1 (ZEB1) is highly expressed upon
differentiation of human embryonic stem cells (hESCs) into neuronal precursors.
CRISPR/Cas9-mediated ZEB1 depletion did not impede neural fate commitment, but …
However, a risk for tumor formation and difficulties in generating large amounts of subtype
derivatives remain the major obstacles for clinical applications of stem cells. Here, we
discovered that zinc finger E-box–binding homeobox 1 (ZEB1) is highly expressed upon
differentiation of human embryonic stem cells (hESCs) into neuronal precursors.
CRISPR/Cas9-mediated ZEB1 depletion did not impede neural fate commitment, but …