Early T lineage progenitors: new insights, but old questions remain
A Bhandoola, A Sambandam, D Allman… - The Journal of …, 2003 - journals.aai.org
A Bhandoola, A Sambandam, D Allman, A Meraz, B Schwarz
The Journal of Immunology, 2003•journals.aai.orgT cells developing in the adult thymus ultimately derive from self-renewing hemopoietic stem
cells (HSCs) 2 in the bone marrow (BM). An understanding of the developmental steps
linking HSCs to T cells is critical for understanding the T cell defects in aging, the process of
malignant transformation in T lineage cells, improving T cell reconstitution after
immunotherapy or BM transplantation, and devising gene therapy approaches to correct
defects of T cell development and function. In this review, we summarize recent insights into …
cells (HSCs) 2 in the bone marrow (BM). An understanding of the developmental steps
linking HSCs to T cells is critical for understanding the T cell defects in aging, the process of
malignant transformation in T lineage cells, improving T cell reconstitution after
immunotherapy or BM transplantation, and devising gene therapy approaches to correct
defects of T cell development and function. In this review, we summarize recent insights into …
T cells developing in the adult thymus ultimately derive from self-renewing hemopoietic stem cells (HSCs) 2 in the bone marrow (BM). An understanding of the developmental steps linking HSCs to T cells is critical for understanding the T cell defects in aging, the process of malignant transformation in T lineage cells, improving T cell reconstitution after immunotherapy or BM transplantation, and devising gene therapy approaches to correct defects of T cell development and function. In this review, we summarize recent insights into T cell origins, focusing chiefly on adult mice.
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