[HTML][HTML] Exosomes derived from hypoxic leukemia cells enhance tube formation in endothelial cells
H Tadokoro, T Umezu, K Ohyashiki, T Hirano… - Journal of Biological …, 2013 - ASBMB
Hypoxia plays an important role during the evolution of cancer cells and their
microenvironment. Emerging evidence suggests communication between cancer cells and
their microenvironment occurs via exosomes. This study aimed to clarify whether hypoxia
affects angiogenic function through exosomes secreted from leukemia cells. We used the
human leukemia cell line K562 for exosome-generating cells and human umbilical vein
endothelial cells (HUVECs) for exosome target cells. Exosomes derived from K562 cells …
microenvironment. Emerging evidence suggests communication between cancer cells and
their microenvironment occurs via exosomes. This study aimed to clarify whether hypoxia
affects angiogenic function through exosomes secreted from leukemia cells. We used the
human leukemia cell line K562 for exosome-generating cells and human umbilical vein
endothelial cells (HUVECs) for exosome target cells. Exosomes derived from K562 cells …