Inborn errors underlying herpes simplex encephalitis: From TLR3 to IRF3

SY Zhang, JL Casanova - 2015 - rupress.org
2015rupress.org
Model for receptor–ligand interactions for sporozoite traversal of Kupffer cells: Interactions
between circumsporozoite protein (CSP) and glycosaminoglycans (GAGs) are required for
initial sporozoite (SPZ) attachment and sporozoite arrest in the liver sinusoid. The sporozoite
then glides until it encounters a Kupffer cell. Recognition of CD68 as the receptor on Kupffer
cells mediates sporozoite traversal.
Model for receptor–ligand interactions for sporozoite traversal of Kupffer cells: Interactions between circumsporozoite protein (CSP) and glycosaminoglycans (GAGs) are required for initial sporozoite (SPZ) attachment and sporozoite arrest in the liver sinusoid. The sporozoite then glides until it encounters a Kupffer cell. Recognition of CD68 as the receptor on Kupffer cells mediates sporozoite traversal.
rupress.org