Design and biological evaluation of imidazo [1, 2-a] pyridines as novel and potent ASK1 inhibitors
Y Terao, H Suzuki, M Yoshikawa, H Yashiro… - Bioorganic & medicinal …, 2012 - Elsevier
Y Terao, H Suzuki, M Yoshikawa, H Yashiro, S Takekawa, Y Fujitani, K Okada, Y Inoue…
Bioorganic & medicinal chemistry letters, 2012•ElsevierImidazo [1, 2-a] pyridine derivatives were designed, synthesized, and evaluated as inhibitors
of the apoptosis signal-regulating kinase 1 (ASK1). These were based on a benzothiazole
derivative that was discovered from high-throughput screening of our compound library. As a
result, we identified potent, selective, and orally bioavailable ASK1 inhibitors for wide range
of therapeutic targets.
of the apoptosis signal-regulating kinase 1 (ASK1). These were based on a benzothiazole
derivative that was discovered from high-throughput screening of our compound library. As a
result, we identified potent, selective, and orally bioavailable ASK1 inhibitors for wide range
of therapeutic targets.
Imidazo[1,2-a]pyridine derivatives were designed, synthesized, and evaluated as inhibitors of the apoptosis signal-regulating kinase 1 (ASK1). These were based on a benzothiazole derivative that was discovered from high-throughput screening of our compound library. As a result, we identified potent, selective, and orally bioavailable ASK1 inhibitors for wide range of therapeutic targets.
Elsevier