Transforming growth factor β1 improves wound healing and random flap survival in normal and irradiated rats
AV Nall, RE Brownlee, CP Colvin… - … –Head & Neck …, 1996 - jamanetwork.com
Objectives: To evaluate the effect of chronic irradiation on wound healing and random flap
survival (FV), and the effect of transforming growth factor β 1 (TGFβ 1) in this setting using an
animal model. Design: A randomized, controlled study with four groups of rats to study the
effect of irradiation 4 months before surgical intervention. The effect of TGF-β 1 on FV and
wound healing also was evaluated in the irradiated and nonirradiated groups. Subjects:
Ninety-five rats were available for evaluation. Group 1 (n= 10) was the control; group 2 (n …
survival (FV), and the effect of transforming growth factor β 1 (TGFβ 1) in this setting using an
animal model. Design: A randomized, controlled study with four groups of rats to study the
effect of irradiation 4 months before surgical intervention. The effect of TGF-β 1 on FV and
wound healing also was evaluated in the irradiated and nonirradiated groups. Subjects:
Ninety-five rats were available for evaluation. Group 1 (n= 10) was the control; group 2 (n …
