NG2-expressing glial progenitor cells: an abundant and widespread population of cycling cells in the adult rat CNS
MRL Dawson, A Polito, JM Levine… - Molecular and Cellular …, 2003 - Elsevier
Glial progenitor cells of the developing CNS committed to the oligodendrocyte lineage
(OPCs) express the chondroitin sulfate proteoglycan, NG2. A proportion of OPCs fail to
differentiate past the stage at which they express NG2 and the lipid antigen O4 and persist in
the adult CNS in a phenotypically immature form. However, the physiological function of
NG2+ cells in the adult CNS is unknown. Using antibodies against NG2 we show that NG2 is
expressed by a distinct cell population in the mature CNS with the homogeneous antigenic …
(OPCs) express the chondroitin sulfate proteoglycan, NG2. A proportion of OPCs fail to
differentiate past the stage at which they express NG2 and the lipid antigen O4 and persist in
the adult CNS in a phenotypically immature form. However, the physiological function of
NG2+ cells in the adult CNS is unknown. Using antibodies against NG2 we show that NG2 is
expressed by a distinct cell population in the mature CNS with the homogeneous antigenic …