[HTML][HTML] IL-10-producing CD4+ T cells negatively regulate fucosylation of epithelial cells in the gut

Y Goto, A Lamichhane, M Kamioka, S Sato, K Honda… - Scientific reports, 2015 - nature.com
Y Goto, A Lamichhane, M Kamioka, S Sato, K Honda, J Kunisawa, H Kiyono
Scientific reports, 2015nature.com
Fucosylated glycans on the surface of epithelial cells (ECs) regulate intestinal homeostasis
by serving as attachment receptors and a nutrient source for some species of bacteria. We
show here that epithelial fucosylation in the ileum is negatively regulated by IL-10-producing
CD4+ T cells. The number of fucosylated ECs was increased in the ileum of mice lacking T
cells, especially those expressing αβ T cell receptor (TCR), CD4 and IL-10. No such effect
was observed in mice lacking B cells. Adoptive transfer of αβTCR+ CD4+ T cells from normal …
Abstract
Fucosylated glycans on the surface of epithelial cells (ECs) regulate intestinal homeostasis by serving as attachment receptors and a nutrient source for some species of bacteria. We show here that epithelial fucosylation in the ileum is negatively regulated by IL-10-producing CD4+ T cells. The number of fucosylated ECs was increased in the ileum of mice lacking T cells, especially those expressing αβ T cell receptor (TCR), CD4 and IL-10. No such effect was observed in mice lacking B cells. Adoptive transfer of αβTCR+ CD4+ T cells from normal mice, but not IL-10-deficient mice, normalized fucosylation of ECs. These findings suggest that IL-10-producing CD4+ T cells contribute to the maintenance of the function of ECs by regulating their fucosylation.
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