[HTML][HTML] Ex vivo application of carbon monoxide in University of Wisconsin solution to prevent intestinal cold ischemia/reperfusion injury
A Nakao, H Toyokawa, A Tsung, MA Nalesnik… - American journal of …, 2006 - Elsevier
Carbon monoxide (CO), a byproduct of heme catalysis, was shown to have potent
cytoprotective and anti-inflammatory effects. In vivo recipient CO inhalation at low
concentrations prevented ischemia/reperfusion (I/R) injury associated with small intestinal
transplantation (SITx). This study examined whether ex vivo delivery of CO in University of
Wisconsin (UW) solution could ameliorate intestinal I/R injury. Orthotopic syngenic SITx was
performed in Lewis rats after 6 h cold preservation in control UW or UW that was bubbled …
cytoprotective and anti-inflammatory effects. In vivo recipient CO inhalation at low
concentrations prevented ischemia/reperfusion (I/R) injury associated with small intestinal
transplantation (SITx). This study examined whether ex vivo delivery of CO in University of
Wisconsin (UW) solution could ameliorate intestinal I/R injury. Orthotopic syngenic SITx was
performed in Lewis rats after 6 h cold preservation in control UW or UW that was bubbled …