The type III secretion system of Pseudomonas aeruginosa: infection by injection

AR Hauser - Nature Reviews Microbiology, 2009 - nature.com
Nature Reviews Microbiology, 2009nature.com
Abstract The Gram-negative bacterium Pseudomonas aeruginosa uses a complex type III
secretion apparatus to inject effector proteins into host cells. The configuration of this
secretion machinery, the activities of the proteins that are injected by it and the
consequences of this process for infection are now being elucidated. This Review
summarizes our current knowledge of P. aeruginosa type III secretion, including the
secretion and translocation machinery, the regulation of this machinery, and the associated …
Abstract
The Gram-negative bacterium Pseudomonas aeruginosa uses a complex type III secretion apparatus to inject effector proteins into host cells. The configuration of this secretion machinery, the activities of the proteins that are injected by it and the consequences of this process for infection are now being elucidated. This Review summarizes our current knowledge of P. aeruginosa type III secretion, including the secretion and translocation machinery, the regulation of this machinery, and the associated chaperones and effector proteins. The features of this interesting secretion system have important implications for the pathogenesis of P. aeruginosa infections and for other type III secretion systems.
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