CD1 expression on antigen-presenting cells

SK Dougan, A Kaser, RS Blumberg - T Cell Activation by CD1 and Lipid …, 2007 - Springer
SK Dougan, A Kaser, RS Blumberg
T Cell Activation by CD1 and Lipid Antigens, 2007Springer
CD1 proteins present self and microbial glycolipids to CD1-restricted T cells, or in the case
of CD1d, to NKT cells. The CD1 family in humans consists of group I proteins CD1a, CD1b,
CD1c, and CD1e and the group II protein CD1d. Rodents express only CD1d, but as CD1d
is broadly expressed and traffics to all endosomal compartments, this single CD1 family
member is thereby able to acquire antigens in
Abstract
CD1 proteins present self and microbial glycolipids to CD1-restricted T cells, or in the case of CD1d, to NKT cells. The CD1 family in humans consists of group I proteins CD1a, CD1b, CD1c, and CD1e and the group II protein CD1d. Rodents express only CD1d, but as CD1d is broadly expressed and traffics to all endosomal compartments, this single CD1 family member is thereby able to acquire antigens in
Springer