Modulation of hepatic gene expression by hepatocyte nuclear factor 1
E Ktistaki, I Talianidis - Science, 1997 - science.org
E Ktistaki, I Talianidis
Science, 1997•science.orgHepatocyte nuclear factors 1 and 4 (HNF-1 and HNF-4) are liver-enriched transcription
factors that function in the regulation of several liver-specific genes. HNF-1 activates genes
containing promoters with HNF-1 binding sites. However, this factor negatively regulates its
own expression and that of other HNF-4–dependent genes that lack HNF-1 binding sites in
their promoter region. This repression is exerted by a direct interaction of HNF-1 with AF2,
the main activation domain of HNF-4. The dual functions of gene activation and repression …
factors that function in the regulation of several liver-specific genes. HNF-1 activates genes
containing promoters with HNF-1 binding sites. However, this factor negatively regulates its
own expression and that of other HNF-4–dependent genes that lack HNF-1 binding sites in
their promoter region. This repression is exerted by a direct interaction of HNF-1 with AF2,
the main activation domain of HNF-4. The dual functions of gene activation and repression …
Hepatocyte nuclear factors 1 and 4 (HNF-1 and HNF-4) are liver-enriched transcription factors that function in the regulation of several liver-specific genes. HNF-1 activates genes containing promoters with HNF-1 binding sites. However, this factor negatively regulates its own expression and that of other HNF-4–dependent genes that lack HNF-1 binding sites in their promoter region. This repression is exerted by a direct interaction of HNF-1 with AF2, the main activation domain of HNF-4. The dual functions of gene activation and repression suggest that HNF-1 is a global regulator of the transcriptional network involved in the maintenance of hepatocyte-specific phenotype.
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