Mouse models of graft-versus-host disease: advances and limitations

MA Schroeder, JF DiPersio - Disease models & …, 2011 - journals.biologists.com
MA Schroeder, JF DiPersio
Disease models & mechanisms, 2011journals.biologists.com
The limiting factor for successful hematopoietic stem cell transplantation (HSCT) is graft-
versus-host disease (GvHD), a post-transplant disorder that results from immune-mediated
attack of recipient tissue by donor T cells contained in the transplant. Mouse models of
GvHD have provided important insights into the pathophysiology of this disease, which have
helped to improve the success rate of HSCT in humans. The kinetics with which GvHD
develops distinguishes acute from chronic GvHD, and it is clear from studies of mouse …
The limiting factor for successful hematopoietic stem cell transplantation (HSCT) is graft-versus-host disease (GvHD), a post-transplant disorder that results from immune-mediated attack of recipient tissue by donor T cells contained in the transplant. Mouse models of GvHD have provided important insights into the pathophysiology of this disease, which have helped to improve the success rate of HSCT in humans. The kinetics with which GvHD develops distinguishes acute from chronic GvHD, and it is clear from studies of mouse models of GvHD (and studies of human HSCT) that the pathophysiology of these two forms is also distinct. Mouse models also further the basic understanding of the immunological responses involved in GvHD pathology, such as antigen recognition and presentation, the involvement of the thymus and immune reconstitution after transplantation. In this Perspective, we provide an overview of currently available mouse models of acute and chronic GvHD, highlighting their benefits and limitations, and discuss research and clinical opportunities for the future.
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