Control of immunity by the TNFR-related molecule OX40 (CD134)

M Croft - Annual review of immunology, 2009 - annualreviews.org
M Croft
Annual review of immunology, 2009annualreviews.org
TNFR/TNF superfamily members can control diverse aspects of immune function. Research
over the past 10 years has shown that one of the most important and prominent interactions
in this family is that between OX40 (CD134) and its partner OX40L (CD252). These
molecules strongly regulate conventional CD4 and CD8 T cells, and more recent data are
highlighting their ability to modulate NKT cell and NK cell function as well as to mediate
cross-talk with professional antigen-presenting cells and diverse cell types such as mast …
TNFR/TNF superfamily members can control diverse aspects of immune function. Research over the past 10 years has shown that one of the most important and prominent interactions in this family is that between OX40 (CD134) and its partner OX40L (CD252). These molecules strongly regulate conventional CD4 and CD8 T cells, and more recent data are highlighting their ability to modulate NKT cell and NK cell function as well as to mediate cross-talk with professional antigen-presenting cells and diverse cell types such as mast cells, smooth muscle cells, and endothelial cells. Additionally, OX40-OX40L interactions alter the differentiation and activity of regulatory T cells. Blocking OX40L has produced strong therapeutic effects in multiple animal models of autoimmune and inflammatory disease, and, in line with a prospective clinical future, reagents that stimulate OX40 signaling are showing promise as adjuvants for vaccination as well as for treatment of cancer.
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