Nuclear receptor activation in liver leads to coordinated alteration of the expression of
multiple gene products with attendant phenotypic changes of hepatocytes. Peroxisome
proliferators including endogenous fatty acids, environmental chemicals, and drugs induce a
multi-enzyme metabolic response that affects lipid and fatty acid processing. We studied the
signaling network for the peroxisome proliferator-associated receptor alpha (PPARα) in
primary human hepatocytes using the selective PPARα ligand, GW7647. We measured …