[HTML][HTML] Crystal structure of anti-polysialic acid antibody single chain Fv fragment complexed with octasialic acid: insight into the binding preference for polysialic acid

M Nagae, A Ikeda, M Hane, S Hanashima… - Journal of Biological …, 2013 - ASBMB
Polysialic acid is a linear homopolymer of α2–8-linked sialic acids attached mainly onto
glycoproteins. Cell surface polysialic acid plays roles in cell adhesion and differentiation
events in a manner that is often dependent on the degree of polymerization (DP). Anti-
oligo/polysialic acid antibodies have DP-dependent antigenic specificity, and such
antibodies are widely utilized in biological studies for detecting and distinguishing between
different oligo/polysialic acids. A murine monoclonal antibody mAb735 has a unique …