[HTML][HTML] Genetic variability affects the development of brown adipocytes in white fat but not in interscapular brown fats⃞

B Xue, JS Rim, JC Hogan, AA Coulter, RA Koza… - Journal of lipid …, 2007 - ASBMB
Cold exposure induces brown adipocytes in retroperitoneal fat (RP) of adult A/J mice but not
in C57BL/6J (B6) mice. In contrast, induction of the mitochondrial uncoupling protein 1 gene
(Ucp1) in interscapular brown adipose tissue (iBAT) shows no strain dependence. We now
show that unlike iBAT, in which Ucp1 was expressed in the fetus and continued throughout
life, in RP, Ucp1 was transiently expressed between 10 and 30 days of age and then
disappeared. Similar to the lack of genetic variation in the expression of Ucp1 in iBAT during …