[HTML][HTML] Epidermal growth factor plays a crucial role in mitogenic regulation of human brain tumor stem cells
A Soeda, A Inagaki, N Oka, Y Ikegame, H Aoki… - Journal of biological …, 2008 - ASBMB
A cancer stem cell population in malignant brain tumors takes an essential part in brain
tumor initiation, growth, and recurrence. Growth factors, such as epidermal growth factor,
fibroblast growth factor-2, vascular endothelial growth factor, platelet-derived growth factor,
and hepatocyte growth factor, are shown to support the proliferation of neural stem cells and
also may play key roles in gliomagenesis. However, the responsible growth factor (s), which
controls maintenance of brain tumor stem cells, is not yet uncovered. We have established …
tumor initiation, growth, and recurrence. Growth factors, such as epidermal growth factor,
fibroblast growth factor-2, vascular endothelial growth factor, platelet-derived growth factor,
and hepatocyte growth factor, are shown to support the proliferation of neural stem cells and
also may play key roles in gliomagenesis. However, the responsible growth factor (s), which
controls maintenance of brain tumor stem cells, is not yet uncovered. We have established …