[HTML][HTML] Glioma-initiating cells retain their tumorigenicity through integration of the Sox axis and Oct4 protein
H Ikushima, T Todo, Y Ino, M Takahashi, N Saito… - Journal of Biological …, 2011 - ASBMB
Although the concept of cancer stem cells or cancer-initiating cells had created a new
paradigm for the treatment of malignant tumors, it remains unclear how cancer-initiating cells
can be eradicated. We have previously reported that the transforming growth factor-β (TGF-
β)-Sox4-Sox2 pathway is essential for glioma-initiating cells to retain their stemness, and
inhibition of TGF-β signaling may lead to differentiation of glioma-initiating cells (Ikushima,
H., Todo, T., Ino, Y., Takahashi, M., Miyazawa, K., and Miyazono, K.(2009) Cell Stem Cell 5 …
paradigm for the treatment of malignant tumors, it remains unclear how cancer-initiating cells
can be eradicated. We have previously reported that the transforming growth factor-β (TGF-
β)-Sox4-Sox2 pathway is essential for glioma-initiating cells to retain their stemness, and
inhibition of TGF-β signaling may lead to differentiation of glioma-initiating cells (Ikushima,
H., Todo, T., Ino, Y., Takahashi, M., Miyazawa, K., and Miyazono, K.(2009) Cell Stem Cell 5 …