Reduced activity of Na (+)-K+ ATPase of pancreatic islets in chronic renal failure: role of secondary hyperparathyroidism.

SM Hajjar, GZ Fadda, P Thanakitcharu… - Journal of the …, 1992 - journals.lww.com
Abstract The activity of Na (+)-K+ ATPase of pancreatic islets modulates their insulin
secretion. The study presented here examined the activity of this enzyme in pancreatic islets
of chronic renal failure (CRF) rats in an effort to further delineate the mechanisms of
impaired insulin secretion in CRF. The Vmax of Na (+)-K+ ATPase, but not its Km, and the
ATP content are significantly reduced in islets of CRF rats that have elevated levels of
parathyroid hormone (PTH). These derangements are prevented by prior parathyroidectomy …