The binding of native rabbit beta-very low density lipoproteins (beta-VLDL) to the low density
lipoprotein receptor-related protein (LRP) requires incubation with exogenous
apolipoprotein (apo) E. Inclusion of a mixture of the C apolipoproteins in the incubation
inhibits this binding. In the present study, the ability of the individual C apolipoproteins (CI, C-
II, and C-III) to block binding of beta-VLDL to the LRP was examined by measuring
cholesteryl ester formation in mutant fibroblasts that lack low density lipoprotein receptors or …