[HTML][HTML] Liver as a key organ in the supply, storage, and excretion of copper
EA Roberts, B Sarkar - The American journal of clinical nutrition, 2008 - Elsevier
The liver plays an important role in the disposition of copper. Most dietary copper passes
through the liver where it can be used for protein and energy production or excreted through
the biliary route. Because copper is a prooxidant, its intracellular handling is tightly
managed. In Wilson disease, in which synthesis of ceruloplasmin and biliary excretion of
copper are defective, copper accumulates in the liver and leads to progressive liver damage.
The features of hepatic Wilson disease are highly variable. The spectrum of liver disease …
through the liver where it can be used for protein and energy production or excreted through
the biliary route. Because copper is a prooxidant, its intracellular handling is tightly
managed. In Wilson disease, in which synthesis of ceruloplasmin and biliary excretion of
copper are defective, copper accumulates in the liver and leads to progressive liver damage.
The features of hepatic Wilson disease are highly variable. The spectrum of liver disease …