Glucose-stimulated insulin secretion (GSIS) from pancreatic islet β-cells is central to control
of mammalian fuel homeostasis. Glucose metabolism mediates GSIS in part via ATP-
regulated K+(K ATP) channels, but multiple lines of evidence suggest participation of other
signals. Here we investigated the role of cytosolic NADP-dependent isocitrate
dehydrogenase (ICDc) in control of GSIS in β-cells. Delivery of small interfering RNAs
specific for ICDc caused impairment of GSIS in two independent robustly glucose …