Test accuracy of interferon-γ release assays (IGRAs) for diagnosing TB differs when using
older or precommercial tools and inconsistent diagnostic criteria. This metaanalysis critically
appraises studies investigating sensitivity and specificity of the commercial T-Spot. TB and
the QuantiFERON-TB Gold In-Tube Assay (QFT-IT) among definitely confirmed TB cases.
We searched Medline, EMBASE, and Cochrane bibliographies of relevant articles.
Sensitivities, specificities, and indeterminate rates were pooled using a fixed effect model …