The omega‐6 fatty acid derivative 15‐deoxy‐Δ12,14‐prostaglandin J2 is involved in neuroprotection by enteric glial cells against oxidative stress
H Abdo, MM Mahé, P Derkinderen… - The Journal of …, 2012 - Wiley Online Library
H Abdo, MM Mahé, P Derkinderen, K Bach‐Ngohou, M Neunlist, B Lardeux
The Journal of physiology, 2012•Wiley Online LibraryKey points• Enteric glial cells play a major role in the regulation of enteric neuronal
functions.• 15‐Deoxy‐Δ12, 14‐prostaglandin J2 (15d‐PGJ2) is an omega‐6 fatty acid
derivative that was recently identified as a novel glial‐derived mediator involved in the
control of the proliferation and differentiation of intestinal epithelial cells.• In this study, we
show that 15d‐PGJ2 has neuroprotective properties during oxidative stress in the enteric
nervous system.• We furthermore show that 15d‐PGJ2 neuroprotective effects are …
functions.• 15‐Deoxy‐Δ12, 14‐prostaglandin J2 (15d‐PGJ2) is an omega‐6 fatty acid
derivative that was recently identified as a novel glial‐derived mediator involved in the
control of the proliferation and differentiation of intestinal epithelial cells.• In this study, we
show that 15d‐PGJ2 has neuroprotective properties during oxidative stress in the enteric
nervous system.• We furthermore show that 15d‐PGJ2 neuroprotective effects are …
Key points
- • Enteric glial cells play a major role in the regulation of enteric neuronal functions.
- • 15‐Deoxy‐Δ12,14‐prostaglandin J2 (15d‐PGJ2) is an omega‐6 fatty acid derivative that was recently identified as a novel glial‐derived mediator involved in the control of the proliferation and differentiation of intestinal epithelial cells.
- • In this study, we show that 15d‐PGJ2 has neuroprotective properties during oxidative stress in the enteric nervous system.
- • We furthermore show that 15d‐PGJ2 neuroprotective effects are dependent on the activation of the Nrf2 pathway and are associated with an increase of glutathione synthesis in neurons.
- • This study supports the concept that omega‐6 derivatives might be used in preventive and/or therapeutic strategies for the treatment of enteric neuropathies.
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