Oxidative stress causes renal dopamine D1 receptor dysfunction and hypertension via mechanisms that involve nuclear factor-κB and protein kinase C
AA Banday, FR Fazili… - Journal of the American …, 2007 - journals.lww.com
Renal dopamine, via activation of D1 receptors, plays a role in maintaining sodium
homeostasis and BP. There exists a defect in renal D1 receptor function in hypertension,
diabetes, and aging, conditions that are associated with oxidative stress. However, the exact
underlying mechanism of the oxidative stress–mediated impaired D1 receptor signaling and
hypertension is not known. The effect of oxidative stress on renal D1 receptor function was
investigated in healthy animals. Male Sprague-Dawley rats received tap water (vehicle) and …
homeostasis and BP. There exists a defect in renal D1 receptor function in hypertension,
diabetes, and aging, conditions that are associated with oxidative stress. However, the exact
underlying mechanism of the oxidative stress–mediated impaired D1 receptor signaling and
hypertension is not known. The effect of oxidative stress on renal D1 receptor function was
investigated in healthy animals. Male Sprague-Dawley rats received tap water (vehicle) and …
