Laminin and type IV collagen composition of the glomerular basement membrane changes
during glomerular development and maturation. Although it is known that both glomerular
endothelial cells and podocytes produce different laminin isoforms at the appropriate stages
of development, the cellular origins for the different type IV collagen heterotrimers that
appear during development are unknown. Here, immunoelectron microscopy demonstrated
that endothelial cells, mesangial cells, and podocytes of immature glomeruli synthesize …