[HTML][HTML] The nanomechanics of polycystin-1 extracellular region
F Qian, W Wei, G Germino, A Oberhauser - Journal of Biological Chemistry, 2005 - ASBMB
Recent evidence suggests that polycystin-1 (PC1) acts as a mechanosensor, receiving
signals from the primary cilia, neighboring cells, and extracellular matrix and transduces
them into cellular responses that regulate proliferation, adhesion, and differentiation that are
essential for the control of renal tubules and kidney morphogenesis. PC1 has an unusually
long extracellular region (∼ 3000 amino acids) with a multimodular structure. Proteins with a
similar architecture have structural and mechanical roles. Based on the structural similarities …
signals from the primary cilia, neighboring cells, and extracellular matrix and transduces
them into cellular responses that regulate proliferation, adhesion, and differentiation that are
essential for the control of renal tubules and kidney morphogenesis. PC1 has an unusually
long extracellular region (∼ 3000 amino acids) with a multimodular structure. Proteins with a
similar architecture have structural and mechanical roles. Based on the structural similarities …
