[HTML][HTML] A single amino acid residue constitutes the third dimerization domain essential for the assembly and function of the tetrameric polycystin-2 (TRPP2) channel
S Feng, L Rodat-Despoix, P Delmas… - Journal of Biological …, 2011 - ASBMB
Autosomal dominant polycystic kidney disease (ADPKD), the most common inherited cause
of kidney failure, is caused by mutations in either PKD1 (85%) or PKD2 (15%). The PKD2
protein, polycystin-2 (PC2 or TRPP2), is a member of the transient receptor potential (TRP)
superfamily and functions as a nonselective calcium channel. PC2 has been found to form
oligomers in native tissues, suggesting that similar to other TRP channels, it may form
functional homo-or heterotetramers with other TRP subunits. We have recently …
of kidney failure, is caused by mutations in either PKD1 (85%) or PKD2 (15%). The PKD2
protein, polycystin-2 (PC2 or TRPP2), is a member of the transient receptor potential (TRP)
superfamily and functions as a nonselective calcium channel. PC2 has been found to form
oligomers in native tissues, suggesting that similar to other TRP channels, it may form
functional homo-or heterotetramers with other TRP subunits. We have recently …
