Altered store operated calcium entry increases cyclic 3′, 5′-adenosine monophosphate production and extracellular signal-regulated kinases 1 and 2 …
Mutations in polycystins (PC1 or PC2/TRPP2) cause progressive polycystic liver disease
(PLD). In PC2-defective mice, cyclic 3′, 5′-adenosine monophosphate/protein kinase A
(cAMP/PKA)-dependent activation of extracellular signal-regulated kinase/mammalian target
of rapamycin (ERK-mTOR) signaling stimulates cyst growth. We investigated the
mechanisms connecting PC2 dysfunction to altered Ca 2+ and cAMP production and
inappropriate ERK signaling in PC2-defective cholangiocytes. Cystic cholangiocytes were …
(PLD). In PC2-defective mice, cyclic 3′, 5′-adenosine monophosphate/protein kinase A
(cAMP/PKA)-dependent activation of extracellular signal-regulated kinase/mammalian target
of rapamycin (ERK-mTOR) signaling stimulates cyst growth. We investigated the
mechanisms connecting PC2 dysfunction to altered Ca 2+ and cAMP production and
inappropriate ERK signaling in PC2-defective cholangiocytes. Cystic cholangiocytes were …
