The role of renal research in demonstrating the protective properties of heme oxygenase-1
KA Nath - Kidney international, 2013 - kidney-international.org
4 Kidney International (2013) 84 editorial kidney disease (CKD) that proposed the
hyperfiltration hypothesis. 16 These studies not only substantiated a self-perpetuating
mechanism for CKD but also categorized renal responses as either adaptive or maladaptive,
on the basis of their sequential and integrated effects. For example, increased single
nephron glomerular filtration rate (SNGFR) in nephrons surviving after subtotal renal
ablation lessens the acute reduction in whole-kidney glomerular filtration rate (GFR) …
hyperfiltration hypothesis. 16 These studies not only substantiated a self-perpetuating
mechanism for CKD but also categorized renal responses as either adaptive or maladaptive,
on the basis of their sequential and integrated effects. For example, increased single
nephron glomerular filtration rate (SNGFR) in nephrons surviving after subtotal renal
ablation lessens the acute reduction in whole-kidney glomerular filtration rate (GFR) …