Sulfatide-reactive natural killer T cells abrogate ischemia-reperfusion injury
SH Yang, JP Lee, HR Jang, R Cha… - Journal of the …, 2011 - journals.lww.com
There is a significant immune response to ischemia-reperfusion injury (IRI), but the role of
immunomodulatory natural killer T (NKT) cell subtypes is not well understood. Here, we
compared the severity of IRI in mice deficient in type I/II NKT cells (CD1d−/−) or type I NKT
cells (Jα18−/−). The absence of NKT cells, especially type II NKT cells, accentuated the
severity of renal injury, whereas repletion of NKT cells attenuated injury. Adoptively
transferred NKT cells trafficked into the tubulointerstitium, which is the primary area of injury …
immunomodulatory natural killer T (NKT) cell subtypes is not well understood. Here, we
compared the severity of IRI in mice deficient in type I/II NKT cells (CD1d−/−) or type I NKT
cells (Jα18−/−). The absence of NKT cells, especially type II NKT cells, accentuated the
severity of renal injury, whereas repletion of NKT cells attenuated injury. Adoptively
transferred NKT cells trafficked into the tubulointerstitium, which is the primary area of injury …
