Recent longitudinal cohort studies have suggested that episodes of acute kidney injury (AKI)
with only small transient decreases in kidney function are associated with the subsequent
development of chronic kidney disease (CKD). 1-6 Both CKD and, more recently, AKI are
well recognized as global public health issues, associated with significant morbidity and
mortality and resultant health care economic burden. There is considerable conceptual
overlap and interplay between the underlying pathophysiology and pathology, definition …