Although metabolic derangement plays a central role in diabetic nephropathy, a better
understanding of secondary mediators of injury may lead to new therapeutic strategies.
Expression of macrophage migration inhibitory factor (MIF) is increased in experimental
diabetic nephropathy, and increased tubulointerstitial mRNA expression of its receptor,
CD74, has been observed in human diabetic nephropathy. Whether CD74 transduces MIF
signals in podocytes, however, is unknown. Here, we found glomerular and tubulointerstitial …