[HTML][HTML] Determination of aberrant O-glycosylation in the IgA1 hinge region by electron capture dissociation fourier transform-ion cyclotron resonance mass …
MB Renfrow, HJ Cooper, M Tomana, R Kulhavy… - Journal of Biological …, 2005 - ASBMB
In a number of human diseases of chronic inflammatory or autoimmune character,
immunoglobulin molecules display aberrant glycosylation patterns of N-or O-linked glycans.
In IgA nephropathy, IgA1 molecules with incompletely galactosylated O-linked glycans in the
hinge region (HR) are present in mesangial immunodeposits and in circulating immune
complexes. It is not known whether the Gal deficiency in IgA1 proteins occurs randomly or
preferentially at specific sites. To develop experimental approaches to address this question …
immunoglobulin molecules display aberrant glycosylation patterns of N-or O-linked glycans.
In IgA nephropathy, IgA1 molecules with incompletely galactosylated O-linked glycans in the
hinge region (HR) are present in mesangial immunodeposits and in circulating immune
complexes. It is not known whether the Gal deficiency in IgA1 proteins occurs randomly or
preferentially at specific sites. To develop experimental approaches to address this question …