Coexistence of different circulating anti-podocyte antibodies in membranous nephropathy
C Murtas, M Bruschi, G Candiano… - Clinical Journal of the …, 2012 - journals.lww.com
Results IgG 4 was the most common isotype for all antibodies; IgG 1 and IgG 3 were nearly
negligible. IgG 4 levels were positive in a significant proportion of MN patients (AR, 34%;
SOD2, 28%; αENO, 43%). Antibody titers were higher in MN than in healthy and pathologic
controls (P< 0.005). Anti-NEP IgG 4 did not differ from normal controls (P= 0.12). Anti-PLA2r
IgG 4 was detected in 60% of patients and correlated with anti-AR, anti-SOD2, and anti-
αENO IgG 4 (P< 0.001). In MN patients negative for the whole antibody panel (20%), 1-year …
negligible. IgG 4 levels were positive in a significant proportion of MN patients (AR, 34%;
SOD2, 28%; αENO, 43%). Antibody titers were higher in MN than in healthy and pathologic
controls (P< 0.005). Anti-NEP IgG 4 did not differ from normal controls (P= 0.12). Anti-PLA2r
IgG 4 was detected in 60% of patients and correlated with anti-AR, anti-SOD2, and anti-
αENO IgG 4 (P< 0.001). In MN patients negative for the whole antibody panel (20%), 1-year …
