[HTML][HTML] Determination of primary versus secondary membranous glomerulopathy utilizing phospholipase A2 receptor staining in renal biopsies
CP Larsen, NC Messias, FG Silva, E Messias… - Modern Pathology, 2013 - Elsevier
Autoantibody formation directed against phospholipase A2 receptor (PLA2R) 1 is the
underlying etiology in most cases of primary membranous glomerulopathy. This new
understanding of the pathogenesis of primary membranous is in the process of transforming
the way the disease is diagnosed. We validated an indirect immunofluorescence assay to
examine PLA2R1 in renal biopsies utilizing a commercially available antibody and standard
indirect immunofluorescence. Using this assay, we examined a total of 165 cases of …
underlying etiology in most cases of primary membranous glomerulopathy. This new
understanding of the pathogenesis of primary membranous is in the process of transforming
the way the disease is diagnosed. We validated an indirect immunofluorescence assay to
examine PLA2R1 in renal biopsies utilizing a commercially available antibody and standard
indirect immunofluorescence. Using this assay, we examined a total of 165 cases of …