Involvement of the mitogen-activated protein kinase c-Jun NH2-terminal kinase 1 in thrombus formation
A Kauskot, F Adam, A Mazharian, N Ajzenberg… - Journal of biological …, 2007 - ASBMB
The involvement of the mitogen-activated protein kinase c-Jun NH 2-terminal kinase-1
(JNK1) has never been investigated in hemostasis and thrombosis. Using two JNK inhibitors
(SP600125 and 6o), we have demonstrated that JNK1 is involved in collagen-induced
platelet aggregation dependent on ADP. In these conditions, JNK1 activation requires the
coordinated signaling pathways of collagen receptors (α2β1 and glycoprotein (GP) VI) and
ADP. In contrast, JNK1 is not required for platelet adhesion on a collagen matrix in static or …
(JNK1) has never been investigated in hemostasis and thrombosis. Using two JNK inhibitors
(SP600125 and 6o), we have demonstrated that JNK1 is involved in collagen-induced
platelet aggregation dependent on ADP. In these conditions, JNK1 activation requires the
coordinated signaling pathways of collagen receptors (α2β1 and glycoprotein (GP) VI) and
ADP. In contrast, JNK1 is not required for platelet adhesion on a collagen matrix in static or …
